Liver morphogenesis

pathway activity — cross-omics
GO:0072576Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Liver morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PCPG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, SUSD6, and IL6ST, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PCPGTNFAIP3 →+1.148+0.032<.001<.001325
UCSSUSD6 →+1.113+0.069<.001<.001324
LAMLIL6ST →+0.889+0.072<.001<.001324
LAMLLRRK2 →+1.362+0.073<.001<.001323
UCSCFLAR →+0.882+0.069<.001<.001323
KIRPENTPD1 →+0.655+0.037<.001<.001322
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration