Terminal button organization

Across TCGA patient cohorts, RNA activity of the Terminal button organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIF1, RPRD2, and RRP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terminal button organization activity versus RIF1 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIF1 →	+0.592	+0.263	<.001	<.001	3	3
LSCC	RPRD2 →	+0.341	+0.276	<.001	<.001	3	3
LSCC	RRP9 →	+0.360	+0.250	<.001	<.001	3	3
LSCC	SART1 →	+0.330	+0.273	<.001	<.001	3	3
BRCA	ATAD2 →	+0.433	+0.171	<.001	<.001	3	3
LSCC	SF3A3 →	+0.230	+0.208	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072553 vs RIF1 — LSCC

Explore this scatter interactively →