T-helper 17 cell lineage commitment

Across TCGA patient cohorts, RNA activity of the T-helper 17 cell lineage commitment pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1, STK10, and THEMIS2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell lineage commitment activity versus FMNL1 in LSCC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FMNL1 →	+0.585	+0.095	<.001	<.001	3	10
LSCC	STK10 →	+0.428	+0.084	<.001	<.001	3	9
LSCC	THEMIS2 →	+0.507	+0.086	<.001	<.001	3	9
BRCA	THEMIS2_T593 →	+0.808	+0.066	<.001	<.001	3	9
LSCC	WIPF1 →	+0.397	+0.097	<.001	<.001	3	9
LSCC	BIN2 →	+0.566	+0.099	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072540 vs FMNL1 — LSCC

Explore this scatter interactively →