T-helper 17 cell lineage commitment

Across TCGA patient cohorts, RNA activity of the T-helper 17 cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHCR7, BCL7A, and NIPSNAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell lineage commitment activity versus DHCR7 in LSCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DHCR7 →	-0.669	-0.549	.008	.003	3	4
HNSC	BCL7A →	-0.426	-0.144	.001	<.001	3	4
HNSC	NIPSNAP1 →	-0.499	-0.164	.003	<.001	3	4
GBM	IGHV3-15 →	+1.016	+0.147	.001	.001	3	4
LSCC	DFFA →	-0.377	-0.609	.004	.001	3	4
LSCC	IGLL5 →	+0.770	+0.437	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072540 vs DHCR7 — LSCC

Explore this scatter interactively →