T-helper 17 cell lineage commitment

Across TCGA cell cohorts, RNA activity of the T-helper 17 cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELOVL1, POU2F2, and TSPAN13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell lineage commitment activity versus ELOVL1 in BLOOD_Lymphoma (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ELOVL1 →	+0.767	+0.805	.001	.005	3	4
PANCREAS	POU2F2 →	+0.908	+1.838	.003	<.001	3	4
BLOOD_Leukemia	TSPAN13 →	-3.438	-0.847	<.001	.006	3	3
BLOOD_Leukemia	CD72 →	-2.114	-0.774	.006	.003	3	3
BLOOD_Lymphoma	HECTD3 →	+0.831	+0.776	<.001	.008	3	3
BLOOD_Lymphoma	SLC10A3 →	+1.164	+1.352	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072540 vs ELOVL1 — BLOOD_Lymphoma

Explore this scatter interactively →