T-helper 17 cell differentiation

Across TCGA patient cohorts, RNA activity of the T-helper 17 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCG2, RCSD1, and STX11, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell differentiation activity versus PLCG2 in GBM (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCG2 →	+0.629	+0.084	<.001	<.001	3	9
BRCA	RCSD1 →	+0.644	+0.057	<.001	<.001	3	7
GBM	STX11 →	+0.593	+0.076	<.001	<.001	3	7
GBM	WAS →	+0.672	+0.089	<.001	<.001	3	7
LSCC	CCDC88B_S597 →	+0.640	+0.053	<.001	<.001	3	7
BRCA	CYBA →	+0.475	+0.029	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072539 vs PLCG2 — GBM

Explore this scatter interactively →