T-helper 17 cell differentiation

Across TCGA patient cohorts, RNA activity of the T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSD2, NEIL3, and PCDH17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell differentiation activity versus NSD2 in UCEC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NSD2 →	-0.420	-0.401	.002	.007	3	4
UCEC	NEIL3 →	-0.691	-0.370	.003	.006	3	3
UCEC	PCDH17 →	+0.496	+0.434	.005	.004	3	3
UCEC	HOXD10 →	+0.603	+0.351	<.001	.001	3	3
UCEC	CDC25A →	-0.601	-0.311	.001	.005	3	3
PDAC	KCNJ3 →	-0.595	-0.425	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072539 vs NSD2 — UCEC

Explore this scatter interactively →