T-helper 17 cell differentiation

Across TCGA patient cohorts, RNA activity of the T-helper 17 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC7_S487, PIK3AP1_S174, and TLN1_S446, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell differentiation activity versus HDAC7_S487 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HDAC7_S487 →	+0.685	+0.943	.001	.002	3	4
OV	PIK3AP1_S174 →	+1.593	+0.731	<.001	<.001	3	4
GBM	TLN1_S446 →	+0.386	+0.692	<.001	<.001	3	3
GBM	NUP98_S623 →	+0.443	+1.012	<.001	<.001	3	3
OV	ATF7 →	+0.585	+0.473	<.001	.002	3	3
UCEC	TCF12_S333 →	+0.809	+0.568	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072539 vs HDAC7_S487 — LUAD

Explore this scatter interactively →