T-helper 17 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC38A9, MSMO1, and EPB41, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC38A9 grouped by T-helper 17 cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC38A9 →	+0.758	+0.150	<.001	.001	3	5
LIVER	MSMO1 →	-1.203	-0.533	.007	.001	3	4
BLOOD_Leukemia	EPB41 →	-1.500	-0.211	.005	.003	3	4
BLOOD_Leukemia	AP2B1 →	-0.606	-0.204	.005	.002	3	4
BREAST	ZNF772 →	+1.139	+0.144	<.001	.003	3	4
LIVER	PDLIM1 →	-1.516	-0.560	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC38A9 by T-helper 17 cell differentiation activity — BREAST

Explore this box plot interactively →