T-helper 17 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 17 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB5, ACLY, and PSMB6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMB5 grouped by T-helper 17 cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PSMB5 →	-0.509	-0.147	<.001	.001	3	8
BREAST	ACLY →	-0.459	-0.196	<.001	<.001	3	6
BLOOD_Leukemia	PSMB6 →	-0.424	-0.123	<.001	<.001	3	6
LIVER	SOHLH1 →	+0.288	+0.115	.002	.003	3	5
OVARY	CDK13 →	-0.211	-0.111	.007	.005	2	6
LUNG_NSCLC_LUAD	NME6 →	-0.153	-0.125	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMB5 by T-helper 17 cell differentiation activity — OVARY

Explore this box plot interactively →