T-helper 17 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL7A, DLG1, and NADK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell differentiation activity versus BCL7A in BLOOD_Myeloma (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	BCL7A →	+2.168	+0.299	<.001	<.001	3	7
BLOOD_Myeloma	DLG1 →	-0.880	-0.295	.001	<.001	3	7
SOFT_TISSUE	NADK →	+1.062	+0.451	.007	<.001	3	6
OVARY	HNRNPC →	+0.770	+0.513	<.001	<.001	3	6
LIVER	RBM14 →	+0.809	+0.408	.002	.003	3	6
LIVER	RCOR2 →	+1.617	+0.437	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072539 vs BCL7A — BLOOD_Myeloma

Explore this scatter interactively →