T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the T-helper 17 type immune response pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2_T593, DOCK10, and FMNL1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 type immune response activity versus THEMIS2_T593 in LSCC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	THEMIS2_T593 →	+0.865	+0.077	<.001	<.001	3	10
LSCC	DOCK10 →	+0.475	+0.072	<.001	<.001	3	10
GBM	FMNL1 →	+0.742	+0.093	<.001	<.001	3	10
GBM	LCP2 →	+0.541	+0.073	<.001	<.001	3	10
LSCC	ARHGAP25 →	+0.575	+0.069	<.001	<.001	3	10
GBM	ARHGDIB →	+0.652	+0.083	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072538 vs THEMIS2_T593 — LSCC

Explore this scatter interactively →