T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC2, OVOL2, and PRKCQ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 type immune response activity versus LRRC2 in HNSC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRRC2 →	+0.993	+0.223	<.001	<.001	3	5
BRCA	OVOL2 →	-0.550	-0.223	.001	<.001	3	5
UCEC	PRKCQ →	+0.894	+0.183	<.001	<.001	3	5
LSCC	SFMBT2 →	+0.803	+0.639	<.001	<.001	3	5
UCEC	MPP1 →	+0.618	+0.159	.001	.002	3	4
LSCC	CASKIN1 →	-0.636	-0.377	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072538 vs LRRC2 — HNSC

Explore this scatter interactively →