T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOF, SLC38A9, and FNIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYOF grouped by T-helper 17 type immune response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYOF →	+1.817	+0.193	.007	<.001	3	5
BREAST	SLC38A9 →	+0.582	+0.153	.002	.002	3	5
BLOOD_Myeloma	FNIP1 →	+0.772	+0.197	.008	.006	2	5
LIVER	MSMO1 →	-1.143	-0.503	.009	.001	3	4
LUNG_SCLC	TRANK1 →	+1.376	+0.293	<.001	<.001	3	4
BLOOD_Leukemia	LYST →	+2.575	+0.200	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYOF by T-helper 17 type immune response activity — BREAST

Explore this box plot interactively →