T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the T-helper 17 type immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK13, PSMB5, and ACLY, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDK13 grouped by T-helper 17 type immune response-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDK13 →	-0.216	-0.108	.002	.003	3	8
BLOOD_Leukemia	PSMB5 →	-0.436	-0.115	.001	.001	3	6
BREAST	ACLY →	-0.406	-0.131	<.001	<.001	3	6
LIVER	SSR1 →	+0.335	+0.120	.002	<.001	3	6
PANCREAS	NECAB2 →	-0.305	-0.136	.001	.009	3	5
LUNG_NSCLC_LUSC	PSMB6 →	-0.436	-0.142	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK13 by T-helper 17 type immune response activity — OVARY

Explore this box plot interactively →