T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR76, METTL21A, and FDX1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 type immune response activity versus WDR76 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WDR76 →	+1.154	+0.519	.003	.003	3	7
PANCREAS	METTL21A →	+0.854	+0.336	.002	.002	3	7
BONE	FDX1 →	+1.561	+0.345	.001	.008	3	6
BONE	HDHD2 →	+1.134	+0.442	<.001	.002	3	6
OVARY	PARP1 →	+1.063	+0.345	<.001	<.001	3	6
LIVER	SNX4 →	+1.244	+0.432	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072538 vs WDR76 — UPPER_AERODIGESTIVE_TRACT

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