Fibroblast activation

Across TCGA patient cohorts, RNA activity of the Fibroblast activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP12, MGP, and C7, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast activation activity versus AKAP12 in GBM (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AKAP12 →	+1.031	+0.574	<.001	<.001	3	10
UCEC	MGP →	+1.892	+1.061	<.001	<.001	3	9
COAD	C7 →	+1.635	+0.656	<.001	.001	3	9
LSCC	IGFBP7 →	+0.572	+0.888	<.001	<.001	3	9
LSCC	INMT →	+0.969	+0.831	<.001	<.001	3	9
BRCA	ASPA →	+0.520	+0.794	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072537 vs AKAP12 — GBM

Explore this scatter interactively →