Fibroblast activation

Across TCGA cell cohorts, RNA activity of the Fibroblast activation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED28, EDA2R, and FDXR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED28 grouped by Fibroblast activation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MED28 →	+0.832	+1.403	<.001	<.001	3	5
SKIN	EDA2R →	+2.145	+0.972	.001	.004	3	5
SKIN	FDXR →	+1.319	+1.177	<.001	<.001	3	5
OVARY	MX1 →	-2.630	-1.175	<.001	.001	3	5
CNS	CHI3L1 →	-2.315	-0.742	.006	.004	3	4
KIDNEY	C4A →	-1.328	-0.959	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED28 by Fibroblast activation activity — OVARY

Explore this box plot interactively →