Fibroblast activation

Across TCGA cell cohorts, RNA activity of the Fibroblast activation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY11, H2AC4, and FUCA1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P2RY11 grouped by Fibroblast activation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	P2RY11 →	-0.156	-1.786	.006	<.001	3	3
LARGE_INTESTINE	H2AC4 →	-0.160	-1.889	.004	<.001	3	3
OVARY	FUCA1 →	-0.390	-1.900	.003	.009	3	3
LARGE_INTESTINE	DGKQ →	+0.242	+1.548	<.001	.003	3	3
LARGE_INTESTINE	PDCD4 →	-0.323	-1.889	.009	<.001	3	3
LUNG_SCLC	CHN2 →	+0.346	+1.844	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P2RY11 by Fibroblast activation activity — SOFT_TISSUE

Explore this box plot interactively →