Pyrimidine-containing compound transmembrane transport

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HNRNPL_S52, ANKRD11_S1847, and APOBR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound transmembrane transport activity versus HNRNPL_S52 in UCEC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HNRNPL_S52 →	-0.335	-0.062	.002	.002	3	5
LUAD	ANKRD11_S1847 →	-0.579	-0.068	.001	.001	3	4
PDAC	APOBR →	+0.276	+0.046	.001	.006	3	4
PDAC	SLC4A2 →	+0.350	+0.050	.003	.001	3	4
LSCC	TM6SF1 →	+0.286	+0.038	.007	.002	2	5
BRCA	TAX1BP3 →	-0.227	-0.043	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072531 vs HNRNPL_S52 — UCEC

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