Pyrimidine-containing compound transmembrane transport

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAM1, VTI1BP1, and WASF1P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound transmembrane transport activity versus NCAM1 in OV (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NCAM1 →	-1.254	-0.824	.001	.001	3	4
GBM	VTI1BP1 →	+0.238	+0.694	.005	.003	3	3
OV	WASF1P1 →	+0.049	+0.923	.004	.002	3	3
BRCA	GOLGA2P7 →	+0.404	+0.378	<.001	<.001	3	3
PDAC	FGD1 →	-0.302	-0.200	<.001	.003	3	3
CCRCC	APLP1 →	-0.593	-0.605	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072531 vs NCAM1 — OV

Explore this scatter interactively →