Pyrimidine-containing compound transmembrane transport

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RERGL, RIOK1, and TNFSF4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RERGL grouped by Pyrimidine-containing compound transmembrane transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RERGL →	+0.190	+0.297	.001	.001	3	2
LARGE_INTESTINE	RIOK1 →	+0.354	+0.296	<.001	.001	3	2
BREAST	TNFSF4 →	+0.380	+0.523	.002	.003	3	2
LARGE_INTESTINE	NAT1 →	-0.463	-0.391	.002	.001	3	1
LARGE_INTESTINE	NEUROD2 →	+0.225	+0.296	.003	.001	3	1
LARGE_INTESTINE	PRPF8 →	-0.330	-0.297	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RERGL by Pyrimidine-containing compound transmembrane transport activity — LARGE_INTESTINE

Explore this box plot interactively →