Purine-containing compound transmembrane transport

Across TCGA cell cohorts, RNA activity of the Purine-containing compound transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB1A, MZF1, and PWWP3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB1A grouped by Purine-containing compound transmembrane transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RAB1A →	-0.483	-1.084	.006	.002	3	4
LUNG_SCLC	MZF1 →	+0.795	+0.870	.009	.001	3	4
PANCREAS	PWWP3A →	-0.714	-1.110	.001	.002	3	4
PANCREAS	HNRNPH1 →	-0.710	-0.991	.001	.004	3	4
OESOPHAGUS	VAX2 →	-1.022	-0.899	<.001	.004	3	4
OESOPHAGUS	TMEM263 →	-1.131	-1.239	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB1A by Purine-containing compound transmembrane transport activity — LUNG_SCLC

Explore this box plot interactively →