Purine-containing compound transmembrane transport

Across TCGA cell cohorts, RNA activity of the Purine-containing compound transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A24, CA5B, and DHRSX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine-containing compound transmembrane transport activity versus SLC25A24 in LIVER (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC25A24 →	+2.578	+0.300	.002	<.001	3	9
BREAST	CA5B →	+1.078	+0.162	.002	.006	3	5
BREAST	DHRSX →	+1.262	+0.233	<.001	.001	3	5
BREAST	ZNF630 →	+0.840	+0.240	.002	.008	3	5
KIDNEY	CES2 →	+1.237	+0.184	.006	.004	3	5
UPPER_AERODIGESTIVE_TRACT	URGCP →	+1.075	+0.248	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072530 vs SLC25A24 — LIVER

Explore this scatter interactively →