Pyrimidine-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM4_T110, FEN1, and PARP14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound biosynthetic process activity versus MCM4_T110 in LUAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM4_T110 →	+0.851	+0.028	.001	.001	3	5
LSCC	FEN1 →	+0.283	+0.023	.008	.002	3	5
LSCC	PARP14 →	+0.208	+0.022	.003	<.001	3	5
BRCA	CMPK2 →	+0.416	+0.013	<.001	.005	3	5
GBM	PLOD3 →	-0.358	-0.018	.001	.002	3	5
OV	SH3BP5 →	-0.913	-0.054	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072528 vs MCM4_T110 — LUAD

Explore this scatter interactively →