Pyrimidine-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CA4, LDB2, and SLC4A7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound biosynthetic process activity versus CA4 in CCRCC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CA4 →	-1.359	-0.157	<.001	<.001	3	4
UCEC	LDB2 →	-0.797	-0.250	<.001	<.001	3	4
GBM	SLC4A7 →	+0.331	+0.145	.005	.001	3	4
GBM	DKK3 →	-0.730	-0.247	.001	<.001	3	4
PDAC	CENPF →	+0.567	+0.163	.003	<.001	3	4
LSCC	SLC25A19 →	+0.361	+0.152	.003	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072528 vs CA4 — CCRCC

Explore this scatter interactively →