Pyrimidine-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, LONP1, and WIZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound biosynthetic process activity versus CSNK1G2 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CSNK1G2 →	+0.730	+0.858	<.001	.008	3	6
OVARY	LONP1 →	+1.123	+0.948	.001	.005	3	5
BONE	WIZ →	+1.213	+0.453	.005	.006	3	5
BLOOD_Leukemia	AAAS →	+0.421	+0.200	<.001	<.001	3	5
KIDNEY	PPP1R9B →	+0.916	+0.252	.002	<.001	3	5
BLOOD_Leukemia	TCF12 →	+1.224	+0.228	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072528 vs CSNK1G2 — BREAST

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