Pyrimidine-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EXOC7_S283, GOLGA3_S22, and WNK2_S1862, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound metabolic process activity versus EXOC7_S283 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EXOC7_S283 →	+0.418	+0.019	.002	<.001	3	5
LSCC	GOLGA3_S22 →	-0.498	-0.026	.001	.002	3	5
PDAC	WNK2_S1862 →	+1.037	+0.024	<.001	<.001	3	5
GBM	PPM1H_T113 →	+0.791	+0.020	<.001	<.001	3	5
CCRCC	SND1_S645 →	-0.876	-0.023	<.001	.001	3	5
UCEC	SLC38A2 →	-0.543	-0.034	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072527 vs EXOC7_S283 — LSCC

Explore this scatter interactively →