Pyrimidine-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A7, LYN, and IL2RA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound metabolic process activity versus SLC4A7 in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC4A7 →	+0.356	+0.146	.003	<.001	3	4
CCRCC	LYN →	+0.397	+0.133	.002	.004	3	4
BRCA	IL2RA →	+0.583	+0.161	<.001	<.001	3	4
PDAC	TRGVA →	-0.217	-0.098	.001	.002	3	3
HNSC	SNAP23P1 →	+0.553	+0.102	.009	.001	3	3
LUAD	IL21R →	+0.626	+0.109	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072527 vs SLC4A7 — LUAD

Explore this scatter interactively →