Pyrimidine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, MRPL45P2, and ZFPM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TYMS grouped by Pyrimidine-containing compound metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TYMS →	-0.600	-0.213	<.001	.001	3	6
URINARY_TRACT	MRPL45P2 →	-0.470	-0.337	.001	.001	3	5
BLOOD_Leukemia	ZFPM2 →	+0.137	+0.251	.005	<.001	3	5
LIVER	PAK1IP1 →	+0.327	+0.230	.001	.001	3	4
LIVER	SULT1C4 →	+0.301	+0.264	.001	.007	3	4
LIVER	HOXC8 →	+0.170	+0.224	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TYMS by Pyrimidine-containing compound metabolic process activity — BREAST

Explore this box plot interactively →