Pyrimidine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB12, B3GNT3, and C5orf15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB12 grouped by Pyrimidine-containing compound metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAB12 →	-1.089	-0.235	<.001	.006	3	4
LIVER	B3GNT3 →	+2.898	+0.223	.003	.001	3	4
BONE	C5orf15 →	-0.879	-0.236	.004	.009	3	4
BONE	PALLD →	-3.002	-0.189	.003	.003	3	4
BONE	DMXL1 →	-0.719	-0.207	.004	<.001	3	4
LUNG_NSCLC_LUAD	FAAH →	+1.448	+0.193	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB12 by Pyrimidine-containing compound metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →