Pyrimidine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSD, SQSTM1, and NASP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound metabolic process activity versus CTSD in SOFT_TISSUE (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CTSD →	-1.982	-0.387	.001	.002	3	7
LUNG_SCLC	SQSTM1 →	-1.143	-0.252	.001	<.001	3	6
BLOOD_Leukemia	NASP →	+0.465	+0.176	<.001	<.001	3	5
BLOOD_Leukemia	WDR33 →	+0.424	+0.180	<.001	<.001	3	5
BLOOD_Leukemia	SCAF4 →	+0.901	+0.296	<.001	<.001	3	5
BLOOD_Leukemia	PAXIP1 →	+0.980	+0.284	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072527 vs CTSD — SOFT_TISSUE

Explore this scatter interactively →