Pyridine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Pyridine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SARM1, MBTD1, and KANSL1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound catabolic process activity versus SARM1 in CHOL (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	SARM1 →	+1.029	+0.057	<.001	<.001	3	30
DLBC	MBTD1 →	+0.945	+0.052	<.001	<.001	3	29
DLBC	KANSL1 →	+0.930	+0.060	<.001	<.001	3	29
DLBC	CCDC93 →	+0.860	+0.063	<.001	<.001	3	29
DLBC	ZNF236 →	+1.248	+0.065	<.001	<.001	3	29
DLBC	INTS3 →	+1.298	+0.063	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072526 vs SARM1 — CHOL

Explore this scatter interactively →