Pyridine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Pyridine-containing compound catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BPNT1, MICALL1, and HMGN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound catabolic process activity versus BPNT1 in UCEC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BPNT1 →	+0.429	+0.078	.001	.001	3	5
LSCC	MICALL1 →	-0.262	-0.053	.005	.002	3	5
GBM	HMGN5 →	+0.750	+0.056	<.001	.004	3	4
CCRCC	MEPCE_S152 →	+0.361	+0.025	.001	<.001	3	4
UCEC	NUCKS1 →	+0.307	+0.046	.002	.002	3	4
COAD	SEC14L1 →	-0.865	-0.039	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072526 vs BPNT1 — UCEC

Explore this scatter interactively →