Pyridine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Pyridine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF10, DNAJC18, and THPO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound catabolic process activity versus FGF10 in BRCA (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGF10 →	+1.481	+0.126	.003	.003	3	6
BRCA	DNAJC18 →	+0.361	+0.124	.004	.002	3	6
CCRCC	THPO →	+0.781	+0.117	<.001	.001	3	6
PDAC	NEGR1 →	+0.592	+0.152	.002	<.001	3	6
COAD	ASPA →	+0.276	+0.093	.002	.004	3	6
BRCA	CBX7 →	+0.715	+0.171	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072526 vs FGF10 — BRCA

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