Pyridine-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Pyridine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2AK4, E4F1, and HAGH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2AK4 grouped by Pyridine-containing compound catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EIF2AK4 →	+0.671	+0.328	.005	.009	3	5
URINARY_TRACT	E4F1 →	-0.805	-0.322	.001	.005	3	5
LUNG_NSCLC_LUAD	HAGH →	-0.581	-0.457	.006	.007	2	6
BONE	KRIT1 →	-0.774	-0.396	.003	<.001	3	5
LIVER	BCOR →	-0.816	-0.291	<.001	.001	3	4
LUNG_NSCLC_LUSC	TARBP1 →	-1.171	-0.432	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2AK4 by Pyridine-containing compound catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →