Pyridine-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Pyridine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMC2, TRIM24, and SRGN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound catabolic process activity versus LAMC2 in STOMACH (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LAMC2 →	-3.942	-0.226	.002	.002	3	5
BLOOD_Leukemia	TRIM24 →	-0.702	-0.152	<.001	.005	3	5
LUNG_NSCLC_LUAD	SRGN →	+5.889	+0.223	<.001	<.001	3	5
SKIN	LONRF3 →	+1.572	+0.287	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MFF →	+0.793	+0.166	<.001	<.001	3	5
BREAST	GALK2 →	+0.662	+0.161	.002	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072526 vs LAMC2 — STOMACH

Explore this scatter interactively →