Pyridine-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyridine-containing compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP8L, ZMYM2, and SNRPD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound biosynthetic process activity versus AKAP8L in OV (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AKAP8L →	-0.388	-0.036	<.001	.002	3	7
GBM	ZMYM2 →	-0.251	-0.031	.008	.005	3	5
LSCC	SNRPD2 →	-0.167	-0.033	<.001	<.001	3	5
CCRCC	SP4_S46 →	-0.260	-0.047	<.001	.001	3	5
BRCA	TLE3 →	-0.318	-0.031	<.001	<.001	3	5
OV	POGZ →	-0.178	-0.028	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072525 vs AKAP8L — OV

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