Pyridine-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyridine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD274, CCRL2, and HCST, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound biosynthetic process activity versus CD274 in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD274 →	+0.940	+0.217	.005	.001	3	6
GBM	CCRL2 →	+0.702	+0.146	<.001	.001	3	6
OV	HCST →	+0.736	+0.240	<.001	<.001	3	6
GBM	LILRB2 →	+0.979	+0.173	<.001	<.001	3	6
OV	GNLY →	+1.408	+0.282	.001	<.001	3	6
LUAD	ABI3 →	+0.435	+0.206	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072525 vs CD274 — HNSC

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