Pyridine-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyridine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF1D, C17orf78, and PAX6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF1D grouped by Pyridine-containing compound biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TAF1D →	+0.979	+0.987	<.001	.001	3	4
BREAST	C17orf78 →	-0.037	-0.884	.008	.003	3	4
LUNG_NSCLC_LUSC	PAX6 →	+2.096	+0.272	.003	.003	3	4
URINARY_TRACT	JPH2 →	-2.657	-0.535	.003	<.001	3	4
LUNG_SCLC	GCNT1 →	+2.495	+0.272	.005	.001	3	4
BREAST	TEX12 →	+0.142	+0.927	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF1D by Pyridine-containing compound biosynthetic process activity — BREAST

Explore this box plot interactively →