Pyridine-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyridine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF330, TBC1D30, and RGS16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound biosynthetic process activity versus ZNF330 in LIVER (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZNF330 →	+0.567	+0.416	.001	.003	3	5
LIVER	TBC1D30 →	+2.211	+0.399	.002	.005	3	5
LARGE_INTESTINE	RGS16 →	+1.640	+0.376	<.001	.001	3	5
LUNG_NSCLC_LUAD	PCCB →	+0.733	+0.375	.003	.007	3	5
URINARY_TRACT	TRMU →	+0.936	+0.438	.003	<.001	3	4
URINARY_TRACT	MTMR6 →	+0.689	+0.271	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072525 vs ZNF330 — LIVER

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