Pyridine-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Pyridine-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPD1, EPB41L3, and DOCK2_S1592, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound metabolic process activity versus GPD1 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPD1 →	+0.683	+0.028	<.001	<.001	3	6
GBM	EPB41L3 →	+0.688	+0.046	<.001	<.001	3	6
PDAC	DOCK2_S1592 →	+0.418	+0.021	<.001	<.001	3	5
UCEC	INPP5D_S971 →	+0.383	+0.038	.006	.001	3	5
OV	PLIN5_S140 →	+1.483	+0.042	.007	.001	3	5
BRCA	RCSD1 →	+0.424	+0.019	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072524 vs GPD1 — GBM

Explore this scatter interactively →