Pyridine-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Pyridine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC69, CYTH4, and CCRL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound metabolic process activity versus CCDC69 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCDC69 →	+0.819	+0.228	<.001	<.001	3	8
HNSC	CYTH4 →	+1.045	+0.164	<.001	<.001	3	7
GBM	CCRL2 →	+0.796	+0.173	<.001	<.001	3	7
GBM	GPR65 →	+0.628	+0.123	.003	.003	3	7
GBM	MYO1F →	+0.891	+0.180	<.001	<.001	3	7
BRCA	RAB37 →	+0.604	+0.165	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072524 vs CCDC69 — BRCA

Explore this scatter interactively →