Pyridine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Pyridine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDOC, GPI, and TSPAN7, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound metabolic process activity versus ALDOC in OVARY (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ALDOC →	+2.270	+0.056	<.001	<.001	3	12
LUNG_NSCLC_LUAD	GPI →	+0.823	+0.062	<.001	.003	3	11
LUNG_NSCLC_LUSC	TSPAN7 →	+3.402	+0.074	.002	.001	3	10
SOFT_TISSUE	LGALS3BP →	+3.362	+0.049	<.001	<.001	3	9
OVARY	CDK18 →	+1.359	+0.042	.005	.006	3	9
CNS	SH3BP1 →	+1.345	+0.058	<.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072524 vs ALDOC — OVARY

Explore this scatter interactively →