Purine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Purine-containing compound catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNL3, SF3B6, and RPL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine-containing compound catabolic process activity versus GNL3 in BRCA (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GNL3 →	-0.389	-0.018	.001	.009	3	5
OV	SF3B6 →	-0.258	-0.030	.002	.004	3	5
GBM	RPL5 →	-0.174	-0.039	.002	.001	3	5
UCEC	ME1 →	+0.439	+0.027	.002	.008	3	5
GBM	OPTN →	+0.508	+0.039	.001	.004	3	5
COAD	SNX2 →	+0.182	+0.016	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072523 vs GNL3 — BRCA

Explore this scatter interactively →