Purine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Purine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALOX5, KIAA1958, and LST1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine-containing compound catabolic process activity versus ALOX5 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALOX5 →	+0.809	+0.130	.002	.001	3	7
HNSC	KIAA1958 →	-0.525	-0.158	<.001	.003	3	6
UCEC	LST1 →	+0.782	+0.156	.004	.002	3	6
LSCC	FCGR2A →	+0.832	+0.225	<.001	<.001	3	6
HNSC	CCR5 →	+0.783	+0.200	.002	<.001	3	6
HNSC	NEMP1 →	-0.630	-0.169	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072523 vs ALOX5 — GBM

Explore this scatter interactively →