Purine-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Purine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AXL, RRM1, and IRF2BP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AXL grouped by Purine-containing compound catabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	AXL →	+4.642	+0.261	.002	.004	3	6
KIDNEY	RRM1 →	+0.667	+0.709	.008	.007	3	6
BREAST	IRF2BP2 →	-0.702	-0.390	<.001	.001	3	5
LUNG_SCLC	TOX3 →	-3.487	-0.225	<.001	.003	3	5
LUNG_NSCLC_LUAD	GAREM1 →	-0.657	-0.329	.006	.007	3	5
KIDNEY	SPC25 →	+0.776	+0.799	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AXL by Purine-containing compound catabolic process activity — URINARY_TRACT

Explore this box plot interactively →