Purine-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Purine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNNC1, PPL, and DSC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine-containing compound catabolic process activity versus TNNC1 in LARGE_INTESTINE (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNNC1 →	-2.498	-0.224	<.001	.002	3	6
LARGE_INTESTINE	PPL →	-2.293	-0.311	<.001	<.001	3	6
OVARY	DSC2 →	-2.171	-0.336	.002	.001	3	6
OVARY	HINT1 →	+0.793	+0.309	.002	<.001	3	6
STOMACH	ZEB1 →	+2.222	+0.210	.001	.001	3	6
STOMACH	TSHZ1 →	+2.037	+0.226	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072523 vs TNNC1 — LARGE_INTESTINE

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