Seminiferous tubule development

Across TCGA patient cohorts, RNA activity of the Seminiferous tubule development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF182, LILRA1, and VSIR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Seminiferous tubule development activity versus ZNF182 in OV (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF182 →	+0.354	+0.277	.003	.009	3	5
GBM	LILRA1 →	-0.508	-0.416	<.001	.001	3	5
GBM	VSIR →	-0.953	-0.510	<.001	.001	3	5
HNSC	CEP41 →	+0.424	+0.392	.002	.006	3	4
BRCA	ETS2 →	-0.702	-0.303	<.001	.002	3	4
GBM	IL18 →	-0.717	-0.341	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072520 vs ZNF182 — OV

Explore this scatter interactively →