Ammonium transmembrane transport

Across TCGA patient cohorts, RNA activity of the Ammonium transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, SNX9, and SORBS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ammonium transmembrane transport activity versus ILK in UCEC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ILK →	+0.468	+0.091	.001	<.001	3	8
BRCA	SNX9 →	+0.332	+0.056	<.001	<.001	3	7
BRCA	SORBS2 →	+0.593	+0.054	<.001	<.001	3	7
UCEC	TNS1 →	+0.574	+0.083	.001	.001	3	7
LUAD	ZC3HC1_S24 →	-0.884	-0.122	<.001	.001	3	7
UCEC	RSU1 →	+0.430	+0.094	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072488 vs ILK — UCEC

Explore this scatter interactively →